Synthesis of ethynyl-3-hydroxyquinoline-4-carboxylic acids


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Abstract

3-Hydroxyquinoline-4-carboxylic acids containing ethynyl moiety in the 6th and 8th positions were obtained for the fi rst time. A synthetic approach to aforementioned compounds based on the Sonogashira cross-coupling and the Pfi tzinger reaction was developed. Physicochemical properties of the newly synthesized structures were investigated.

About the authors

S. Yu. Maklakova

Department of Chemistry, M. V. Lomonosov Moscow State University; Laboratory of biomedical nanomaterials, National University of Science and Technology MISiS

Author for correspondence.
Email: MaklakovaSU@yandex.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; 4 Leninskiy prosp., Moscow, 119049

A. D. Chuprov

Department of Chemistry, M. V. Lomonosov Moscow State University

Email: MaklakovaSU@yandex.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991

M. P. Mazhuga

Department of Chemistry, M. V. Lomonosov Moscow State University

Email: MaklakovaSU@yandex.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991

E. K. Beloglazkina

Department of Chemistry, M. V. Lomonosov Moscow State University

Email: MaklakovaSU@yandex.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991

N. V. Zyk

Department of Chemistry, M. V. Lomonosov Moscow State University

Email: MaklakovaSU@yandex.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991

A. G. Majouga

Department of Chemistry, M. V. Lomonosov Moscow State University; D. I. Mendeleev University of Chemical Technology of Russia; Laboratory of biomedical nanomaterials, National University of Science and Technology MISiS

Email: MaklakovaSU@yandex.ru
Russian Federation, Build. 3, 1 Leninskie Gory, Moscow, 119991; 9 Miusskaya pl., Moscow, 125047; 4 Leninskiy prosp., Moscow, 119049

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