Email this article Synthesis of new azolo[5,1-d][1,2,3,5]tetrazin-4-ones–analogs of antitumor agent temozolomide
- Authors: Sadchikova E.V.1
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Affiliations:
- Ural Federal University named after the first President of Russia B. N. Yeltsin
- Issue: Vol 65, No 7 (2016)
- Pages: 1867-1872
- Section: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/238656
- DOI: https://doi.org/10.1007/s11172-016-1522-9
- ID: 238656
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Abstract
Reactivity of 5-diazoimidazoles and 5-diazopyrazoles in the reactions with alkyland aryl isocyanates was studied. A number of new imidazo-and pyrazolo[5,1-d][1,2,3,5]tetrazin-4 ones were synthesized, which are analogs of temozolomide. It was shown that diazoazoles do not react with isothiocyanates under similar conditions.
About the authors
E. V. Sadchikova
Ural Federal University named after the first President of Russia B. N. Yeltsin
Author for correspondence.
Email: e.v.sadchikova@urfu.ru
Russian Federation, 19 ul. Mira, Ekaterinburg, 620002
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