Molecular construction of multitarget neuroprotectors 4.* Synthesis and biological activity of conjugates of carbazoles and tetrahydrocarbazoles


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Abstract

Unknown conjugates of carbazoles and tetrahydrocarbazoles were obtained by the alkylation of carbazoles and tetrahydrocarbazoles with 3,6-substituted 9-oxiranylmethylcarbazoles. The influence of synthesized 1-(9Н-carbazol-9-yl)-3-(1,2,3,4-tetrahydro-5Н-pyrido[4,3-b]-indol-5-yl)propan-2-ones on functional characteristics of brain mitochondria has been studied. The potential neuroprotective activity of a several representatives of conjugates has been demonstrated using glutamate toxicity model.

About the authors

V. B. Sokolov

Institute of Physiologically Active Substances, Russian Academy of Sciences

Author for correspondence.
Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

A. Yu. Aksinenko

Institute of Physiologically Active Substances, Russian Academy of Sciences

Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

T. V. Goreva

Institute of Physiologically Active Substances, Russian Academy of Sciences

Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

T. A. Epishina

Institute of Physiologically Active Substances, Russian Academy of Sciences

Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

L. G. Dubova

Institute of Physiologically Active Substances, Russian Academy of Sciences

Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

E. S. Dubrovskaya

Institute of Physiologically Active Substances, Russian Academy of Sciences

Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

S. G. Klochkov

Institute of Physiologically Active Substances, Russian Academy of Sciences

Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

P. N. Shevtsov

Institute of Physiologically Active Substances, Russian Academy of Sciences

Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

E. F. Shevtsova

Institute of Physiologically Active Substances, Russian Academy of Sciences

Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

S. O. Bachurin

Institute of Physiologically Active Substances, Russian Academy of Sciences

Email: alaks@ipac.ac.ru
Russian Federation, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432

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