Reaction of 5- O -succinoylavermectin B 1  with alkylating agents

E. I. Chernoburova; V. A. Lishchuk; K. L. Ovchinnikov; A. V. Kolobov; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

doi:10.1007/s11172-016-1686-3

Reaction of 5-O-succinoylavermectin B₁ with alkylating agents

Autores: Chernoburova E.I.¹, Lishchuk V.A.², Ovchinnikov K.L.², Kolobov A.V.², Dzhafarov M.K.³, Vasilevich F.I.³, Zavarzin I.V.¹
Afiliações:
1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
2. Yaroslavl State Technical University
3. K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Edição: Volume 65, Nº 12 (2016)
Páginas: 2965-2969
Seção: Full Articles
URL: https://journal-vniispk.ru/1066-5285/article/view/239724
DOI: https://doi.org/10.1007/s11172-016-1686-3
ID: 239724

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Resumo

A reaction of 5-O-succinoylavermectin B₁ with alkylating agents, namely phenacyl halides, bromoacetanilides, and benzyl bromides, was studied. Esters of 5-O-succinoylavermectin B₁ were obtained for the first time, which are of interest as potential antiparasitic agents.