Stereoselective synthesis of 1,3-disubstituted phthalans by cyclization of (1S)-1-{2-[hydroxy(diaryl)methyl]phenyl}ethanols


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Cyclization of pure enantiomers of 1-{2-[hydroxy(diaryl)methyl]phenyl}ethanol proceeds stereoselectively and affords 1,3-disubstituted 1,3-dihydroisobenzofurans (phthalans) in moderate-to-high enantiomeric (81.7% ee) or diastereomeric (72% de) purity.

作者简介

I. Shishkina

Chemical department, M. V. Lomonosov Moscow State University

Email: demyan@org.chem.msu.ru
俄罗斯联邦, 1/3 Leninskie Gory, Moscow, 119991

E. Sokolovskaya

Chemical department, M. V. Lomonosov Moscow State University

Email: demyan@org.chem.msu.ru
俄罗斯联邦, 1/3 Leninskie Gory, Moscow, 119991

V. Demyanovich

Chemical department, M. V. Lomonosov Moscow State University

编辑信件的主要联系方式.
Email: demyan@org.chem.msu.ru
俄罗斯联邦, 1/3 Leninskie Gory, Moscow, 119991

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