Asymptotic Theory for Longitudinal Data with Missing Responses Adjusted by Inverse Probability Weights

Abstract

In this article, we propose a new method for analyzing longitudinal data which contain responses that are missing at random. This method consists in solving the generalized estimating equation (GEE) of [8] in which the incomplete responses are replaced by values adjusted using the inverse probability weights proposed in [17]. We show that the root estimator is consistent and asymptotically normal, essentially under the some conditions on the marginal distribution and the surrogate correlation matrix as those presented in [15] in the case of complete data, and under minimal assumptions on the missingness probabilities. This method is applied to a real-life data set taken from [13], which examines the incidence of respiratory disease in a sample of 250 pre-school age Indonesian children which were examined every 3 months for 18 months, using as covariates the age, gender, and vitamin A deficiency.