New Synthetic Route to CY5-Labeled 2'-Deoxycytidine- 5'-Triphosphates Using Sonogashira Reaction

T. O. Guseinov; V. E. Kuznetsova; V. E. Shershov; M. A. Spitsyn; S. A. Lapa; A. S. Zasedatelev; A. V. Chudinov

doi:10.1134/S1068162018020103

New Synthetic Route to CY5-Labeled 2'-Deoxycytidine- 5'-Triphosphates Using Sonogashira Reaction

Authors: Guseinov T.O.¹, Kuznetsova V.E.¹, Shershov V.E.¹, Spitsyn M.A.¹, Lapa S.A.¹, Zasedatelev A.S.¹, Chudinov A.V.¹
Affiliations:
1. Engelhardt Institute of Molecular Biology
Issue: Vol 44, No 2 (2018)
Pages: 252-255
Section: Letters to the Editor
URL: https://journal-vniispk.ru/1068-1620/article/view/228911
DOI: https://doi.org/10.1134/S1068162018020103
ID: 228911

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Abstract

Herein, we present a new synthetic route to fluorescently-labeled nucleoside triphosphates via Sonogashira cross-coupling of iodinated deoxycytidine monophosphate and cyanine dye with a terminal alkyne group.