Email this article Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells
- Authors: Shmendel E.V.1, Kabilova T.O.2, Morozova N.G.1, Zenkova M.A.2, Maslov M.A.1
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Affiliations:
- Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
- Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
- Issue: Vol 45, No 6 (2019)
- Pages: 719-725
- Section: Article
- URL: https://journal-vniispk.ru/1068-1620/article/view/229314
- DOI: https://doi.org/10.1134/S1068162019060360
- ID: 229314
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Abstract
Targeted cationic liposomes containing folate lipoconjugates with spacer groups of various lengths and natures were prepared; their physicochemical characteristics and their transfection activity towards KB-3-1 and HEK 293 cells were determined. Targeted delivery of plasmid DNA was studied by competitive inhibition of DNA delivery in the presence of free folic acid.
About the authors
E. V. Shmendel
Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Email: mamaslov@mail.ru
Russian Federation, Moscow, 119571
T. O. Kabilova
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
Email: mamaslov@mail.ru
Russian Federation, Novosibirsk, 630090
N. G. Morozova
Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Email: mamaslov@mail.ru
Russian Federation, Moscow, 119571
M. A. Zenkova
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences
Email: mamaslov@mail.ru
Russian Federation, Novosibirsk, 630090
M. A. Maslov
Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University
Author for correspondence.
Email: mamaslov@mail.ru
Russian Federation, Moscow, 119571
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