Synthesis and antimicrobial activity of novel 5-[(1H-indol-3-yl)methylene]thiazolidine-2,4-dione–[1,2,3]triazole hybrids


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Abstract

5-[(1H-Indol-3-yl)methylene]thiazolidine-2,4-dione–[1,2,3]triazole hybrid derivatives were synthesized by click chemistry reaction and screened for antimicrobial activity against Gram positive and Gram negative bacteria and fungal species. All synthesized compounds were characterized by 1H and 13C NMR, IR and MS spectra. Antibacterial study indicated that several products demonstrated high activity and some products were determined to be potentially antifungal active agents.

About the authors

L. Kamala

Department of Chemistry, University College for Women

Email: pvanantha.ou@gmail.com
India, Hyderabad, Telangana, 500007

B. S. Veena

Department of Botany, University College of Science

Email: pvanantha.ou@gmail.com
India, Hyderabad, Telangana, 500007

P. V. Anantha Lakshmi

Department of Chemistry, University College for Women

Author for correspondence.
Email: pvanantha.ou@gmail.com
India, Hyderabad, Telangana, 500007

P. Vasantha

Department of Chemistry, University College for Women

Email: pvanantha.ou@gmail.com
India, Hyderabad, Telangana, 500007

E. Sujatha

Department of Botany, University College of Science

Email: pvanantha.ou@gmail.com
India, Hyderabad, Telangana, 500007

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