Synthesis of 3-(4-fluorophenyl)-3-(4-methoxyphenyl)-1-propanarylamines and their antibacterial activity

N. S. Arutyunyan; L. A. Akopyan; R. A. Akopyan; G. M. Stepanyan; G. A. Panosyan; G. A. Gevorgyan

doi:10.1134/S1070363217060275

Synthesis of 3-(4-fluorophenyl)-3-(4-methoxyphenyl)-1-propanarylamines and their antibacterial activity

Authors: Arutyunyan N.S.¹, Akopyan L.A.¹, Akopyan R.A.¹, Stepanyan G.M.¹, Panosyan G.A.², Gevorgyan G.A.¹
Affiliations:
1. Mnjoyan Institute of Fine Organic Chemistry
2. Molecular Structure Research Center
Issue: Vol 87, No 6 (2017)
Pages: 1300-1304
Section: Letters to the Editor
URL: https://journal-vniispk.ru/1070-3632/article/view/220415
DOI: https://doi.org/10.1134/S1070363217060275
ID: 220415

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Abstract

Condensation of 3-(4-fluorophenyl)-3-(4-methoxyphenyl)-1-propanamine with aromatic aldehydes and ketones followed by the reduction of the obtained azomethines with NaBH₄ afforded secondary propanaryl -amines, whose oxalates and hydrochlorides possess high antibacterial activity.