Synthesis and antimicrobial activity of 10-(5-arylamino-1,3,4-oxadiazol-2-ylmethyl)acridin-9(10 H )-ones

T. N. Kudryavtseva; P. I. Sysoev; S. V. Popkov; L. G. Klimova

doi:10.1134/S1070363217080102

Synthesis and antimicrobial activity of 10-(5-arylamino-1,3,4-oxadiazol-2-ylmethyl)acridin-9(10H)-ones

Authors: Kudryavtseva T.N.¹, Sysoev P.I.¹, Popkov S.V.², Klimova L.G.³
Affiliations:
1. Kursk State University
2. Dmitry Mendeleev University of Chemical Technology of Russia
3. Kursk State Medical University
Issue: Vol 87, No 8 (2017)
Pages: 1702-1706
Section: Article
URL: https://journal-vniispk.ru/1070-3632/article/view/220960
DOI: https://doi.org/10.1134/S1070363217080102
ID: 220960

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Abstract

Intramolecular cyclization of N-aryl-2-[(9-oxoacridin-10(9H)-yl)acetyl]hydrazinecarboxamides afforded new 10-(5-arylamino-1,3,4-oxadiazol-2-ylmethyl)acridin-9(10H)-ones. Some of the synthesized compounds showed a moderate antimicrobial activity against gram-positive and gram-negative bacteria. Keywords: acridone, hydrazide, semicarbazide, 1,3,4-oxadiazole, antibacterial activity