Reaction of diphenylphosphinoylallene derivatives of cytisine

V. K. Brel’; E. Yu. Kovaleva; D. D. Enchev

doi:10.1134/S1070363217080163

Reaction of diphenylphosphinoylallene derivatives of cytisine

Authors: Brel’ V.K.¹, Kovaleva E.Y.¹, Enchev D.D.²
Affiliations:
1. Nesmeyanov Institute of Organoelement Compounds
2. Konstantin Preslavsky University of Shumen
Issue: Vol 87, No 8 (2017)
Pages: 1731-1736
Section: Article
URL: https://journal-vniispk.ru/1070-3632/article/view/220988
DOI: https://doi.org/10.1134/S1070363217080163
ID: 220988

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Abstract

Diphenylphosphinoylallenes containing a ClCH₂ group were synthesized, and their reaction with cytisine was studied. It was shown that the reaction involves exclusives as nucleophilic substitution of chlorine in the chloromethyl group. The synthesized conjugates of cytisine with diphenylphosphinoylallene derivatives are of interest as potential agonists of nicotinic acetylcholine neuroreceptors (nAChRs).