Synthesis of pyrinidine-2,4(1H,3H)-dione derivatives containing N-alkyl substituents


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Abstract

6-Methyluracil derivatives containing a gem-dichlorocyclopropane and a 1,3-dioxolane fragments were synthesized for the first time. The condensation of 6-methyluracil with chloromethyl derivatives gives a mixture of N1- and N3-monosubstituted products, and the profound N-alkylation of this compound provides disubstituted uracils. The structure of the synthesized compounds was studied by H1 and 13С NMR spectroscopy and their relative antioxidant activity was evaluated by luminol-dependent chemiluminescence measurements.

About the authors

V. F. Valiev

Ufa State Petroleum Technological University

Email: graskildina444@mail.ru
Russian Federation, ul. Kosmonavtov 1, Ufa, Bashkortostan, 450062

I. V. Ozden

Ufa State Petroleum Technological University

Email: graskildina444@mail.ru
Russian Federation, ul. Kosmonavtov 1, Ufa, Bashkortostan, 450062

S. A. Meshcheryakova

Bashkir State Medical University

Email: graskildina444@mail.ru
Russian Federation, Ufa, Bashkortostan

L. V. Spirikhin

Ufa Institute of Chemistry

Email: graskildina444@mail.ru
Russian Federation, Ufa, Bashkortostan

S. S. Zlotskii

Ufa State Petroleum Technological University

Email: graskildina444@mail.ru
Russian Federation, ul. Kosmonavtov 1, Ufa, Bashkortostan, 450062

G. Z. Raskildina

Ufa State Petroleum Technological University

Author for correspondence.
Email: graskildina444@mail.ru
Russian Federation, ul. Kosmonavtov 1, Ufa, Bashkortostan, 450062

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