Cyclic Amidoalkylation of Hydrophosphorylic Compounds. Synthesis of Proline Analogs


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Abstract

A method for the synthesis of N-Cbz-protected phosphorylic analogs of proline by cyclic amidoalkylation of various hydrophosphorylic compounds was developed. Combination of amide and carbonyl fragments in the 4-N-Cbz-aminobutyraldehyde molecule allows to realize the three-center two-component amide version of the Kabachnik–Fields reaction.

About the authors

A. V. Vinyukov

Institute of Physiologically Active Substances

Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432

M. E. Dmitriev

Institute of Physiologically Active Substances

Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432

A. N. Yarkevich

Institute of Physiologically Active Substances

Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432

V. V. Ragulin

Institute of Physiologically Active Substances

Author for correspondence.
Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, Moscow oblast, 142432

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