Synthesis of 2-Amino-5-hydroxy-5-phosphonovaleric Acid


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Abstract

The synthesis of a new analog of 2-amino-5-phosphonovaleric acid (AP5), namely 2-amino-5-hydroxy-5-phosphonovaleric acid, by successive Michael addition of acetamidomalonic ester to acrolein and Abramov’s phosphorylation of the aldehydes formed in situ was developed.

About the authors

V. V. Ragulin

Institute of Physiologically Active Substances of the Russian Academy of Sciences

Author for correspondence.
Email: rvalery@dio.ru
Russian Federation, Severnyi proezd 1, Chernogolovka, 142432

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