Synthesis of Functionalized Tris(2-propoxyphenyl)phosphine Oxides as Precursors of Tripodal Propeller-Shaped Ligands

Abstract

A series of precursors of novel tripodal ligands (2-XCH₂CH₂CH₂OC₆H₄)₃PO, where X = AcO, HO, MeSO₂O, Br, N₃, were synthesized by the alkylation of the starting tris(2-hydroxyphenyl)phosphine oxide with 3-bromopropyl acetate followed by hydrolysis of the resulting triacetate to triol and conversion of the latter to trimesylate. Treratment of the resulting trimesylate with LiBr or NaN₃ was used to prepare the corresponding tribromo or triazido derivatives.