Interaction of Glutathione-Stabilized Gold Nanoclusters with Doxorubicin and Polycation


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Glutathione-capped gold nanoclusters display polyanionic properties that are manifested in the interaction with cationic species. The nanoclusters form complexes with doxorubicin with effective dissociation constant about 10 µM that increased by an order of magnitude in the presence of 0.15 M NaCl confirming electrostatic character of binding. Adsorption of polylysine arose an increase in the fluorescence of gold nanoclusters due to aggregation induced emission enhancement effect. Fluorescence of the complexes increased several-fold upon addition of up to 1 M of KCl suggesting contribution of non-Coulombic forces in the stabilization of aggregates of gold nanoclusters.

About the authors

N. P. Iakimov

Lomonosov Moscow State University

Email: melik.nubarov@genebee.msu.ru
Russian Federation, Moscow, 119991

Va. R. Abdullina

Lomonosov Moscow State University

Email: melik.nubarov@genebee.msu.ru
Russian Federation, Moscow, 119991

P. A. Sharanov

Lomonosov Moscow State University

Email: melik.nubarov@genebee.msu.ru
Russian Federation, Moscow, 119991

N. V. Alov

Lomonosov Moscow State University

Email: melik.nubarov@genebee.msu.ru
Russian Federation, Moscow, 119991

V. N. Orlov

Lomonosov Moscow State University

Email: melik.nubarov@genebee.msu.ru
Russian Federation, Moscow, 119991

I. D. Grozdova

Lomonosov Moscow State University

Email: melik.nubarov@genebee.msu.ru
Russian Federation, Moscow, 119991

N. S. Melik-Nubarov

Lomonosov Moscow State University

Author for correspondence.
Email: melik.nubarov@genebee.msu.ru
Russian Federation, Moscow, 119991

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2019 Pleiades Publishing, Ltd.