Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole-Isoxazole Linked Quinazoline Derivatives as Anticancer Agents

M. Srinivas; S. Satyaveni; B. Ram

doi:10.1134/S1070363219120260

Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole-Isoxazole Linked Quinazoline Derivatives as Anticancer Agents

Authors: Srinivas M.¹, Satyaveni S.¹, Ram B.²
Affiliations:
1. Department of Chemistry
2. Green Evolution Laboratories
Issue: Vol 89, No 12 (2019)
Pages: 2492-2497
Section: Article
URL: https://journal-vniispk.ru/1070-3632/article/view/223224
DOI: https://doi.org/10.1134/S1070363219120260
ID: 223224

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Abstract

A series of novel 1,2,4-oxadiazole-isoxazole linked quinazoline compounds is designed, synthesized and screened for anticancer activity on four human cancer cell lines including MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay with etoposide used as a positive reference. All compounds demonstrate good to moderate anticancer activity and two compounds are found to be the most potent.