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Reaction of diphenylphosphinoylallene derivatives of cytisine

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1. Title Title of document Reaction of diphenylphosphinoylallene derivatives of cytisine
2. Creator Author's name, affiliation, country V. K. Brel’; Nesmeyanov Institute of Organoelement Compounds; Russian Federation
2. Creator Author's name, affiliation, country E. Yu. Kovaleva; Nesmeyanov Institute of Organoelement Compounds; Russian Federation
2. Creator Author's name, affiliation, country D. D. Enchev; Konstantin Preslavsky University of Shumen; Bulgaria
3. Subject Discipline(s)
3. Subject Keyword(s) alkaloids; allene; cytisine; phosphine oxides
4. Description Abstract

Diphenylphosphinoylallenes containing a ClCH2 group were synthesized, and their reaction with cytisine was studied. It was shown that the reaction involves exclusives as nucleophilic substitution of chlorine in the chloromethyl group. The synthesized conjugates of cytisine with diphenylphosphinoylallene derivatives are of interest as potential agonists of nicotinic acetylcholine neuroreceptors (nAChRs).

5. Publisher Organizing agency, location Pleiades Publishing, Ltd.
6. Contributor Sponsor(s)
7. Date (DD-MM-YYYY) 01.08.2017
8. Type Status & genre Peer-reviewed Article
8. Type Type Research Article
9. Format File format
10. Identifier Uniform Resource Identifier https://journal-vniispk.ru/1070-3632/article/view/220988
10. Identifier Digital Object Identifier (DOI) 10.1134/S1070363217080163
11. Source Title; vol., no. (year) Russian Journal of General Chemistry; Vol 87, No 8 (2017)
12. Language English=en
13. Relation Supp. Files
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
15. Rights Copyright and permissions Copyright (c) 2017 Pleiades Publishing, Ltd.