Synthesis and biological activity of new 2,6-diphenyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridines

Аннотация

An efficient one-pot synthesis of new 2,6-diphenyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridines is presented. This involves the three-component reaction of aldehydes with ketones and ammonium acetate in the presence of catalytic amount of iodine/AcOH. The newly synthesized compounds were characterized by IR, ¹H, ¹³C NMR spectra, and MS data. The products were screened for antibacterial and antifungal activity. Some of the tested compounds exhibited high activity.