Synthesis of novel 2-phenoxybenzo[g][1,2,4]triazolo[1,5-a]quinazoline and its derivatives starting with diphenyl-N-cyanoimidocarbonate


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Cyclocondensation reaction of 3-hydrazinyl-2-naphthoic acid with diphenyl-N-cyanoimidocarbonate furnished the target 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazolin-5(4H)-one (1) in high yield. Alkylation, thionation and chlorination of the lactam group in the compound 1 produced a variety of derivatives 2–17. Their structures were characterized by NMR and HREI-MS analyses.

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R. Al-Salahi

Department of Pharmaceutical Chemistry, College of Pharmacy

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Email: rashad76@outlook.com
沙特阿拉伯, Riyadh, 11451

M. Marzouk

Department of Pharmaceutical Chemistry, College of Pharmacy; Chemistry of Natural Products Group, Center of Excellence for Advanced Sciences

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Email: msmarzouk@yahoo.co.uk
沙特阿拉伯, Riyadh, 11451; Dokki, Cairo, 12622

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