Synthesis and Biological Evaluation of Amide Derivatives of Imidazopyridine as Anticancer Agents

V. Ramesh; G. Purna Chander Rao; D. Ramachandran; A. Kalyan Chakravarthy

doi:10.1134/S1070363219070193

Synthesis and Biological Evaluation of Amide Derivatives of Imidazopyridine as Anticancer Agents

Авторы: Ramesh V.¹, Rao G.P.¹, Ramachandran D.¹, Chakravarthy A.K.²
Учреждения:
1. Department of Chemistry
2. Integrated Product Development
Выпуск: Том 89, № 7 (2019)
Страницы: 1491-1495
Раздел: Article
URL: https://journal-vniispk.ru/1070-3632/article/view/222999
DOI: https://doi.org/10.1134/S1070363219070193
ID: 222999

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Аннотация

A series of new amide derivatives of imidazopyridine is synthesized and structures of the products are confirmed by ¹H and ¹³C NMR, and mass spectral data. The synthesized derivatives are screened for their anticancer activity against four human cancer cell lines: lung cancer (A549), breast cancer (MCF-7), melanoma cancer (A375), and colon cancer (HT-29). Six synthesized compounds exhibit more potent activity than the control drug.