Email this article Synthesis and heterocyclization of 2-{[2-(4-bromophenyl)-2-oxoethyl]sulfanyl}pyrimidin-4(3h)-ones
- Authors: Frolova T.V.1, Kim D.G.1, Sharutin V.V.1, Shal’kova E.N.1
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Affiliations:
- South Ural State University
- Issue: Vol 52, No 1 (2016)
- Pages: 96-98
- Section: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/213552
- DOI: https://doi.org/10.1134/S1070428016010188
- ID: 213552
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Abstract
Alkylation of sodium 4(5)-alkyl-6-oxo-1,6-dihydropyrimidine-2-thiolates with 2-bromo-1-(4-bromophenyl)ethan-1-one afforded 2-{[2-(4-bromophenyl)-2-oxoethyl]sulfanyl}pyrimidin-4(3H)-ones. Analogous reaction with sodium 4-trifluoromethyl-6-oxo-1,6-dihydropyrimidine-2-thiolate gave a mixture of 2-{[2-(4-bromophenyl)-2-oxoethyl]sulfanyl}-4-(trifluoromethyl)pyrimidin-4(3H)-one and its intramolecular cyclization product, 3-(4-bromophenyl)-3-hydroxy-7-trifluoromethyl-2,3-dihydro[1,3]thiazolo[3,2-a]-pyrimidin-5-one.
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About the authors
T. V. Frolova
South Ural State University
Author for correspondence.
Email: chemitash@gmail.com
Russian Federation, pr. Lenina 76, Chelyabinsk, 454071
D. G. Kim
South Ural State University
Email: chemitash@gmail.com
Russian Federation, pr. Lenina 76, Chelyabinsk, 454071
V. V. Sharutin
South Ural State University
Email: chemitash@gmail.com
Russian Federation, pr. Lenina 76, Chelyabinsk, 454071
E. N. Shal’kova
South Ural State University
Email: chemitash@gmail.com
Russian Federation, pr. Lenina 76, Chelyabinsk, 454071
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