Synthesis and biologic activity of aryloxyaminopropanoles based on substituted  p -tolylalkylamines

A. A. Aghekyan; G. G. Mkryan; A. S. Tsatinyan; O. S. Noravyan; G. V. Gasparyan

doi:10.1134/S1070428016020081

Synthesis and biologic activity of aryloxyaminopropanoles based on substituted p-tolylalkylamines

Authors: Aghekyan A.A.¹, Mkryan G.G.¹, Tsatinyan A.S.¹, Noravyan O.S.¹, Gasparyan G.V.¹
Affiliations:
1. R&D Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of Armenia, Mndzhoyan Institute of Fine Organic Chemistry
Issue: Vol 52, No 2 (2016)
Pages: 209-213
Section: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/213693
DOI: https://doi.org/10.1134/S1070428016020081
ID: 213693

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Abstract

Reaction of 2,2-dimethyl-2-(p-tolyl)ethyl-, 1-p-tolylcyclopenthylmethyl- and 4-(p-tolyl)tetrahydro-2Н-pyran-4-ylmethylamines with phenoxymethyloxiranes substituted in the aromatic ring afforded new aryloxypropanolamines, some of which show moderate adrenoblocking activity.