Synthesis and biologic properties of new thiazolylbenzodioxane derivatives

S. O. Vartanyan; A. S. Avakyan; A. B. Sargsyan; S. A. Arutyunyan; O. S. Noravyan; A. S. Tsatinyan

doi:10.1134/S1070428016020159

Synthesis and biologic properties of new thiazolylbenzodioxane derivatives

Authors: Vartanyan S.O.¹, Avakyan A.S.¹, Sargsyan A.B.¹, Arutyunyan S.A.¹, Noravyan O.S.¹, Tsatinyan A.S.¹
Affiliations:
1. R&D Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of Armenia, Mndzhoyan Institute of Fine Organic Chemistry
Issue: Vol 52, No 2 (2016)
Pages: 244-248
Section: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/213752
DOI: https://doi.org/10.1134/S1070428016020159
ID: 213752

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Abstract

Reaction of 4-(1,4-benzodioxan-2-yl)thiazol-2-amine with acid chlorides afforded N-substituted amides which further were reduced into the corresponding amines. A new method was developed of preparation of 2-acetyl-1,4-benzodioxane, the initial compound in the synthesis of thiazolylbenzodioxane and numerous derivatives of this series. The adreno- and sympatholytic as well as antihypoxic effect of the obtained biheterocyclic 1,4-benzodioxane derivatives were investigated.