Reductive cleavage and subsequent transformations of 5-oxa-6-azaspiro[2.4]heptane-1-carboxylates
- Authors: Molchanov A.P.1, Tran T.Q.2, Stepakov A.V.1, Kostikov R.R.1
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Affiliations:
- St. Petersburg State University
- School of Chemical Engineering
- Issue: Vol 52, No 3 (2016)
- Pages: 404-408
- Section: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/213937
- DOI: https://doi.org/10.1134/S1070428016030180
- ID: 213937
Cite item
Abstract
Treatment of methyl 4,6-diaryl-5-oxa-6-azaspiro[2.4]heptane-1-carboxylates with zinc in acetic acid leads to cleavage of the N–O bond in the isoxazolidine ring with formation of 1,3-amino alcohols whose subsequent cyclization under the reaction conditions yields bi- or tricyclic lactams or lactones with retention of the three-membered ring.
About the authors
A. P. Molchanov
St. Petersburg State University
Author for correspondence.
Email: a.molchanov@spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
T. Q. Tran
School of Chemical Engineering
Email: a.molchanov@spbu.ru
Viet Nam, 1 Dai Co Viet Road, Hanoi
A. V. Stepakov
St. Petersburg State University
Email: a.molchanov@spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
R. R. Kostikov
St. Petersburg State University
Email: a.molchanov@spbu.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
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