Synthesis, structure, and biologic activity of products of reactions between dinitrodichlorobenzofuroxane and aminopyrimidines in aqueous dimethyl sulfoxide

I. V. Galkina; L. M. Yusupova; A. T. Gubaidullin; V. I. Galkin

doi:10.1134/S1070428016050201

Synthesis, structure, and biologic activity of products of reactions between dinitrodichlorobenzofuroxane and aminopyrimidines in aqueous dimethyl sulfoxide

Authors: Galkina I.V.¹, Yusupova L.M.², Gubaidullin A.T.³, Galkin V.I.¹
Affiliations:
1. Kazan (Volga region) Federal University
2. Kazan National Research Technologic University
3. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center
Issue: Vol 52, No 5 (2016)
Pages: 734-739
Section: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/214387
DOI: https://doi.org/10.1134/S1070428016050201
ID: 214387

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Abstract

Reactions of 4,6-dinitro-5,7-dichlorobenzofuroxane with substituted pyrimidines in aqueous DMSO proceed through an intermediate formation of 5-hydroxy-4,6-dinitro-7-chlorobenzofuroxane owing to the hydrolysis of one of the chlorine atoms with the subsequent formation of pyrimidine salts exhibiting a high biologic action.