Interaction of 1,5,6,8-tetrahydropyrazolo[3,4- е ][1,4]diazepine-4,7-diones with some electrophilic reagents

S. V. Kemskii; A. V. Bol’but; S. V. Shishkina; D. A. Mel’nik; M. V. Vovk

doi:10.1134/S107042801608011X

Interaction of 1,5,6,8-tetrahydropyrazolo[3,4-е][1,4]diazepine-4,7-diones with some electrophilic reagents

Authors: Kemskii S.V.¹, Bol’but A.V.¹^,2, Shishkina S.V.³^,4, Mel’nik D.A.⁵, Vovk M.V.¹
Affiliations:
1. Institute of Organic Chemistry
2. R&D Enterprise “Enamin,”
3. Institute of Single Crystals
4. Kharkiv State University
5. Ivano-Frankivsk National Medical University
Issue: Vol 52, No 8 (2016)
Pages: 1162-1167
Section: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/214828
DOI: https://doi.org/10.1134/S107042801608011X
ID: 214828

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Abstract

1,5,6,8-Tetrahydropyrazolo[3,4-e][1,4]diazepine-4,7-diones undergo acylation with acetic anhydride and carbamoylation with p-toluensulfonyl isocyanate at the atom N⁵. Interaction with Vilsmeier- Haack reagent occurs at the atom N⁸, it is followed with the opening of the diazepine cycle and leads to the formation of 2-(1Н-pyrazol-4-yl)-1,3-oxazol-5(4Н)-one derivatives.