Synthesis and antiviral properties of new derivatives of 2-(alkylsulfanyl)-6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methylpyrimidin-4(3 H )-one

I. A. Novakov; A. S. Yablokov; B. S. Orlinson; M. B. Navrotskii; I. A. Kirillov; A. A. Vernigora; A. S. Babushkin; V. V. Kachala; D. Schols

doi:10.1134/S1070428016080169

Synthesis and antiviral properties of new derivatives of 2-(alkylsulfanyl)-6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methylpyrimidin-4(3H)-one

Authors: Novakov I.A.¹, Yablokov A.S.¹, Orlinson B.S.¹, Navrotskii M.B.¹, Kirillov I.A.¹, Vernigora A.A.¹, Babushkin A.S.¹, Kachala V.V.², Schols D.³
Affiliations:
1. Volgograd State Technical University
2. Zelinskii Institute of Organic Chemistry
3. Rega Institute for Medical Research
Issue: Vol 52, No 8 (2016)
Pages: 1188-1193
Section: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/214856
DOI: https://doi.org/10.1134/S1070428016080169
ID: 214856

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Abstract

Based on 2-(2,6-difluorophenyl)acetonitrile a synthesis was performed of new bioisosteric prochiral analogs of anti-HIV-1 active derivatives of 2-alkoxy-6-benzylpyrimidin-4(3Н)-one that we had previously obtained. The study using infected and nonifected strains of cells MT-4 made it possible to find in all prepared compounds a high anti-HIV activity whereas the cytotoxicity of the substances depended strongly on the structure of the alkylsulfanyl fragment of the molecule.