Synthesis of new nucleoside analogs containing amino bisphosphonic groups


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Abstract

Adenosine derivatives containing a 2,2-bis(diethoxyphosphoryl)ethyl or 2,2-diphosphonoethyl group on the amino nitrogen atom were synthesized for the first time by reaction of 5′-chloro-5′-deoxy- and 5′-hydroxy-2′,3′-isopropylideneadenosine with tetraethyl ethene-1,1-diylbis(phosphonate) or tetrakis(trimethylsilyl) ethene-1,1-diylbis(phosphonate).

About the authors

L. I. Vagapova

Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center; Faculty of Chemistry

Author for correspondence.
Email: vagapoval@iopc.ru
Russian Federation, ul. Arbuzova 8, Kazan, Tatarstan, 420088; Leninskie gory 1, Moscow, 119991

A. V. Smolobochkin

Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center

Email: vagapoval@iopc.ru
Russian Federation, ul. Arbuzova 8, Kazan, Tatarstan, 420088

A. S. Gazizov

Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center

Email: vagapoval@iopc.ru
Russian Federation, ul. Arbuzova 8, Kazan, Tatarstan, 420088

A. R. Burilov

Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center; Faculty of Chemistry

Email: vagapoval@iopc.ru
Russian Federation, ul. Arbuzova 8, Kazan, Tatarstan, 420088; Leninskie gory 1, Moscow, 119991

A. A. Bogdanov

Faculty of Chemistry

Email: vagapoval@iopc.ru
Russian Federation, Leninskie gory 1, Moscow, 119991

M. A. Pudovik

Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center

Email: vagapoval@iopc.ru
Russian Federation, ul. Arbuzova 8, Kazan, Tatarstan, 420088

O. G. Sinyashin

Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center

Email: vagapoval@iopc.ru
Russian Federation, ul. Arbuzova 8, Kazan, Tatarstan, 420088

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