Synthesis of 3,5-disubstituted 1,2,4-triazoles containing an amino group
- Авторы: Khromova N.Y.1, Fedorov M.M.1, Malekin S.I.1, Kutkin A.V.1
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Учреждения:
- State Research Institute of Organic Chemistry and Technology
- Выпуск: Том 52, № 10 (2016)
- Страницы: 1490-1495
- Раздел: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/215103
- DOI: https://doi.org/10.1134/S1070428016100195
- ID: 215103
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Аннотация
3,5-Disubstituted 1,2,4-triazoles containing linear and cyclic amine fragments have been synthesized by thermal cyclization of N′-(1-iminoalkyl) hydrazides prepared by condensation of imido esters with carboxylic acid hydrazides. The initial imido esters have been synthesized by the Pinner reaction, as well as by reaction of nitriles with methanol in the presence of a catalytic amount of sodium methoxide. A procedure has been developed for the synthesis of 5-substituted 3-(3-nitrophenyl)-1,2,4-triazoles which have been converted to 3-aminophenyl derivatives by reduction with hydrazine hydrate over Raney nickel.
Об авторах
N. Khromova
State Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Россия, shosse Entuziastov 23, Moscow, 111024
M. Fedorov
State Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Россия, shosse Entuziastov 23, Moscow, 111024
S. Malekin
State Research Institute of Organic Chemistry and Technology
Email: dir@gosniiokht.ru
Россия, shosse Entuziastov 23, Moscow, 111024
A. Kutkin
State Research Institute of Organic Chemistry and Technology
Автор, ответственный за переписку.
Email: dir@gosniiokht.ru
Россия, shosse Entuziastov 23, Moscow, 111024
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