Email this article Design and synthesis of imidazo[4,5-c]pyridine derivatives as promising Aurora kinase A (AURKA) inhibitors
- Authors: Lomov D.A.1, Lyashchuk S.N.1, Abramyants M.G.1
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Affiliations:
- Litvinenko Institute of Physical Organic Chemistry
- Issue: Vol 52, No 12 (2016)
- Pages: 1822-1829
- Section: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/215497
- DOI: https://doi.org/10.1134/S1070428016120198
- ID: 215497
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Abstract
Computer simulation at the PM7 level of theory of the structures of imidazo[4,5-c]pyridine derivatives (deaza analogs of purines) and their complexes with Aurora kinase A (AURKA) indicated prospects for their use as potential AURKA inhibitors in the treatment of oncological diseases. A number of new compounds of the selected imidazo[4,5-c]pyridine series, for which the highest inhibitory activity against AURKA was predicted, were synthesized in high yields for further biological testing.
About the authors
D. A. Lomov
Litvinenko Institute of Physical Organic Chemistry
Author for correspondence.
Email: lomov_dmitrii@mail.ru
Ukraine, ul. Rozy Lyuksemburg 70, Donetsk, 83000
S. N. Lyashchuk
Litvinenko Institute of Physical Organic Chemistry
Email: lomov_dmitrii@mail.ru
Ukraine, ul. Rozy Lyuksemburg 70, Donetsk, 83000
M. G. Abramyants
Litvinenko Institute of Physical Organic Chemistry
Email: lomov_dmitrii@mail.ru
Ukraine, ul. Rozy Lyuksemburg 70, Donetsk, 83000
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