Synthesis and antimicrobial activity of tryptanthrin adducts with ketones


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Reactions of tryptanthrin with acetone, cyclopentanone, hexan-2-one, 4-methylpentan-2-one, 4-hydroxy-4-methylpentan-2-one, cyclohexanone, and butan-2-one in the presence of potassium carbonate afforded racemic phaitanthrin A and other addition products to the ketone group of tryptanthrin with high yields. Thermal dissociation, some chemical transformations, and antimicrobial activity of some adducts were studied, and inhibitory effect against gram-positive bacteria was found for particular derivatives.

作者简介

P. Deryabin

Far Eastern Federal University

Email: moskovkinataisiya@mail.ru
俄罗斯联邦, ul. Sukhanova 8, Vladivostok, 690091

T. Moskovkina

Far Eastern Federal University

编辑信件的主要联系方式.
Email: moskovkinataisiya@mail.ru
俄罗斯联邦, ul. Sukhanova 8, Vladivostok, 690091

L. Shevchenko

Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch

Email: moskovkinataisiya@mail.ru
俄罗斯联邦, pr. 100 let Vladivostoku 159, Vladivostok, 690022

A. Kalinovskii

Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch

Email: moskovkinataisiya@mail.ru
俄罗斯联邦, pr. 100 let Vladivostoku 159, Vladivostok, 690022

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