Three-component synthesis of 3-(diarylmethyl)indoles using Fe(ClO4)3/SiO2 as catalyst


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Abstract

Three-component reaction of indole, aromatic aldehyde, and N,N-dimethyl aniline in the presence of silica-supported Fe(ClO4)3 as catalyst afforded the corresponding 3-[aryl(4-dimethylaminophenyl)methyl]-indoles in excellent yields under mild conditions. The proposed protocol offers some remarkable advantages such as the use of a solid catalyst and simple workup procedure.

About the authors

E. Najafi

Department of Chemistry, Karaj Branch

Email: Farahnazkargar@yahoo.com
Iran, Islamic Republic of, Karaj, 31485313

F. K. Behbahani

Department of Chemistry, Karaj Branch

Author for correspondence.
Email: Farahnazkargar@yahoo.com
Iran, Islamic Republic of, Karaj, 31485313

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