Email this article New facilities of Biginelli reaction. Synthesis of methyl 6-aryl-5-benzoyl-4-methoxy-2-oxohexahydropyrimidine-4-carboxylates
- Authors: Gein V.L.1, Gorgopina E.V.1, Zamaraeva T.M.1, Dmitriev M.V.2
-
Affiliations:
- Perm State Pharmaceutical Academy of the Health Protection Ministry of the Russian Federation
- Perm State National Research University
- Issue: Vol 53, No 11 (2017)
- Pages: 1675-1677
- Section: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/216927
- DOI: https://doi.org/10.1134/S1070428017110100
- ID: 216927
Cite item
Open Access
Access granted
Subscription Access
Abstract
Three-component reaction of methyl benzoylpyruvate, aromatic aldehyde, and urea in methanol in the presence of sodium bisulfate stops at the stage of the formation of nondehydrated product with a methylated tertiary hydroxy group and results in methyl 6-aryl-5-benzoyl-4-methoxy-2-oxohexahydropyrimidine-4-carboxylates.
About the authors
V. L. Gein
Perm State Pharmaceutical Academy of the Health Protection Ministry of the Russian Federation
Author for correspondence.
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
E. V. Gorgopina
Perm State Pharmaceutical Academy of the Health Protection Ministry of the Russian Federation
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
T. M. Zamaraeva
Perm State Pharmaceutical Academy of the Health Protection Ministry of the Russian Federation
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990
M. V. Dmitriev
Perm State National Research University
Email: geinvl48@mail.ru
Russian Federation, Perm, 614990
Supplementary files
