New facilities of Biginelli reaction. Synthesis of methyl 6-aryl-5-benzoyl-4-methoxy-2-oxohexahydropyrimidine-4-carboxylates


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Three-component reaction of methyl benzoylpyruvate, aromatic aldehyde, and urea in methanol in the presence of sodium bisulfate stops at the stage of the formation of nondehydrated product with a methylated tertiary hydroxy group and results in methyl 6-aryl-5-benzoyl-4-methoxy-2-oxohexahydropyrimidine-4-carboxylates.

About the authors

V. L. Gein

Perm State Pharmaceutical Academy of the Health Protection Ministry of the Russian Federation

Author for correspondence.
Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990

E. V. Gorgopina

Perm State Pharmaceutical Academy of the Health Protection Ministry of the Russian Federation

Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990

T. M. Zamaraeva

Perm State Pharmaceutical Academy of the Health Protection Ministry of the Russian Federation

Email: geinvl48@mail.ru
Russian Federation, ul. Polevaya 2, Perm, 614990

M. V. Dmitriev

Perm State National Research University

Email: geinvl48@mail.ru
Russian Federation, Perm, 614990

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2017 Pleiades Publishing, Ltd.