Synthesis of 3-Chloro-4H-imidazo[5,1-c][1,4]benzothiazines and 3-Chloro-4H-5λ6-imidazo[5,1-c][1,4]benzothiazine 5,5-Dioxides


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Abstract

Intramolecular cyclization of S-BBBBB[1-(2-bromoaryl)-4-chloro-1H-imidazol-5-yl]methylBBBBB ethanethioates on heating in DMF in the presence of K2CO3 afforded 3-chloro-4H-imidazo[5,1-c][1,4]benzothiazines which were oxidized with hydrogen peroxide to the corresponding S,S-dioxides.

About the authors

V. A. Chornous

Bukovinian State Medical University

Email: alinagrozav@gmail.com
Ukraine, Teatral’naya pl. 2, Chernovtsy, 58000

A. N. Grozav

Bukovinian State Medical University

Author for correspondence.
Email: alinagrozav@gmail.com
Ukraine, Teatral’naya pl. 2, Chernovtsy, 58000

M. V. Vovk

Institute of Organic Chemistry

Email: alinagrozav@gmail.com
Ukraine, ul. Murmanskaya 5, Kiev, 02660

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