Отправить статью по E-mail Alkylation of 3-Trifluoromethyl-1,2-dihydroquinoxalin-2-one
- Авторы: Ivanova A.E.1, Burgart Y.V.1, Pervova M.G.1, Borisevich S.S.2, Khursan S.L.2, Saloutin V.I.1
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Учреждения:
- Postovskii Institute of Organic Synthesis, Ural branch
- Ufa Institute of Chemistry
- Выпуск: Том 54, № 11 (2018)
- Страницы: 1702-1709
- Раздел: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/219421
- DOI: https://doi.org/10.1134/S1070428018110131
- ID: 219421
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Аннотация
O and N centers of 3-trifluoromethyl-1,2-dihydroquinoxalin-2-one anion shows in reactions with haloalkanes an ambident nucleophilic character. The chemoselectivity of the reaction depends on the alkylating agent: the methylation of 3-trifluoromethyl-1,2-dihydroquinoxalin-2-one in acetonitrile in the presence of K2CO3 yields only an N-methyl isomer whereas under the same conditions in the reaction with (4-bromobutyl)-acetate О- and N-alkylations are competing.
Об авторах
A. Ivanova
Postovskii Institute of Organic Synthesis, Ural branch
Email: saloutin@ios.uran.ru
Россия, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990
Ya. Burgart
Postovskii Institute of Organic Synthesis, Ural branch
Email: saloutin@ios.uran.ru
Россия, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990
M. Pervova
Postovskii Institute of Organic Synthesis, Ural branch
Email: saloutin@ios.uran.ru
Россия, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990
S. Borisevich
Ufa Institute of Chemistry
Email: saloutin@ios.uran.ru
Россия, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
S. Khursan
Ufa Institute of Chemistry
Email: saloutin@ios.uran.ru
Россия, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
V. Saloutin
Postovskii Institute of Organic Synthesis, Ural branch
Автор, ответственный за переписку.
Email: saloutin@ios.uran.ru
Россия, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620990
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