Pyridine—Azepine Structural Modification of 3,4-Dihydro-nor-isoharmine
- 作者: Zubenko A.A.1, Morkovnik A.S.2, Divaeva L.N.2, Kartsev V.G.3, Anisimov A.A.4, Suponitsky K.Y.5
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隶属关系:
- North Caucasus Zonal Research Veterinary Institute, Rostovskoe shosse
- Institute of Physical and Organic Chemistry
- InterBioScreen Ltd.
- Mendeleev University of Chemical Technology of Russia
- Nesmeyanov Institute of Organoelement Compounds
- 期: 卷 55, 编号 1 (2019)
- 页面: 74-82
- 栏目: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/219717
- DOI: https://doi.org/10.1134/S1070428019010081
- ID: 219717
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详细
Structural modification of 3,4-dihydro-nor-isoharmine through expansion of the dihydropyridine ring to dihydroazepine was accomplished in two stages including pyridine-azepine recyclization of the quaternized substrate by the action of phenacyl halides and their heterocyclic analogs. The recyclization process can be accompanied by 1,2-migration of the acyl group to give mixtures of 4-acyl-9-methoxy-3-methyl-1,2-dihydroazepino[4,5-b]indoles and their 5-acyl-substituted isomers. Factor influencing the recyclization direction and product ratio were analyzed.
作者简介
A. Zubenko
North Caucasus Zonal Research Veterinary Institute, Rostovskoe shosse
Email: asmork2@ipoc.rsu.ru
俄罗斯联邦, Novocherkassk, Rostov oblast, 346421
A. Morkovnik
Institute of Physical and Organic Chemistry
编辑信件的主要联系方式.
Email: asmork2@ipoc.rsu.ru
俄罗斯联邦, pr. Stachki 194/2, Rostov-on-Don, 344090
L. Divaeva
Institute of Physical and Organic Chemistry
Email: asmork2@ipoc.rsu.ru
俄罗斯联邦, pr. Stachki 194/2, Rostov-on-Don, 344090
V. Kartsev
InterBioScreen Ltd.
Email: asmork2@ipoc.rsu.ru
俄罗斯联邦, Institutskii pr. 7, Chernogolovka, Moscow oblast, 142432
A. Anisimov
Mendeleev University of Chemical Technology of Russia
Email: asmork2@ipoc.rsu.ru
俄罗斯联邦, Miusskaya pl. 9, Moscow, 125047
K. Suponitsky
Nesmeyanov Institute of Organoelement Compounds
Email: asmork2@ipoc.rsu.ru
俄罗斯联邦, ul. Vavilova 28, Moscow, 119991
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