Synthesis of Polyfunctionalized Hexahydropyrimidines


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Abstract

The reactions of alkyl 5-acetylhexahydropyrimidine-5-carboxylates with ammonia, hydrazine hydrate, and lithium aluminum hydride were used to synthesize hexahydropyrimidine derivatives containing pharmacophoric 1,3-propylenediamine and 1,3-propanolamine fragments.

About the authors

A. G. Badamshin

Ufa Institute of Chemistry, Ufa Research Center; Ufa State Aviation Technical University

Email: dokichev@anrb.ru
Russian Federation, pr. Oktyabrya 69, Ufa, 450054; ul. K. Marksa 12, Ufa, 450008

D. R. Latypova

Ufa Institute of Chemistry, Ufa Research Center

Email: dokichev@anrb.ru
Russian Federation, pr. Oktyabrya 69, Ufa, 450054

V. A. Dokichev

Ufa Institute of Chemistry, Ufa Research Center; Ufa State Aviation Technical University

Author for correspondence.
Email: dokichev@anrb.ru
Russian Federation, pr. Oktyabrya 69, Ufa, 450054; ul. K. Marksa 12, Ufa, 450008

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