Synthesis of Methyl 4-Aryl-4-oxo-2-{4-[(1,3-thiazol-2-yl)-sulfamoyl]phenylamino}but-2-enoates and Their Reactions with Ninhydrin

V. L. Gein; O. V. Bobrovskaya; A. A. Russkikh; M. V. Dmitriev; A. N. Yankin

doi:10.1134/S107042801905004X

Synthesis of Methyl 4-Aryl-4-oxo-2-{4-[(1,3-thiazol-2-yl)-sulfamoyl]phenylamino}but-2-enoates and Their Reactions with Ninhydrin

作者: Gein V.L.¹, Bobrovskaya O.V.¹, Russkikh A.A.¹, Dmitriev M.V.², Yankin A.N.³
隶属关系:
1. Perm State Pharmaceutical Academy
2. Perm State National Research University
3. St. Petersburg State University
期: 卷 55, 编号 5 (2019)
页面: 602-607
栏目: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/220492
DOI: https://doi.org/10.1134/S107042801905004X
ID: 220492

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The reaction of methyl aroylpyruvates with 2-(4-aminobenzenesulfonamido)thiazole (norsulfazole) in acetic acid-ethanol (1: 1) afforded methyl (2Z)-4-aryl-4-oxo-2-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl-amino} but-2-enoates which reacted with ninhydrin in glacial acetic acid to give 4-aroyl-3-{4-[(1,3-thiazol-2-yl)-sulfamoyl]phenylamino} spiro[2,5-dihydrofuran-5,2′-indane]-2,1′,3′-triones.