Email this article A New Synthesis of Calcium N-(5-Hydroxynicotinoyl)-L-glutamate and Its X-ray Diffraction Structure
- Authors: Kiselev A.V.1, Machula A.A.2, Efimov S.I.2, Pashkova E.B.2, Stovbun S.V.1
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Affiliations:
- Semenov Institute of Chemical Physics
- BION
- Issue: Vol 55, No 5 (2019)
- Pages: 615-619
- Section: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/220504
- DOI: https://doi.org/10.1134/S1070428019050063
- ID: 220504
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Abstract
A new synthesis of N-(5-hydroxynicotinoyl)-L-glutamic acid via a 5-hydroxynicotinic acid imidazolide intermediate has been developed. Its calcium salt (Ampasse) has been synthesized and its structure was studied by X-ray diffraction analysis. The reaction conditions for all stages of the process have been optimized and a method for the purification of the substance has been improved.
About the authors
A. V. Kiselev
Semenov Institute of Chemical Physics
Author for correspondence.
Email: icp@chph.ras.ru
Russian Federation, ul. Kosygina 4, Moscow, 119991
A. A. Machula
BION
Email: sefimov@bion-company.ru
Russian Federation, Kievskoe shosse 109 km, Obninsk, Kaluzhskaya obl., 249032
S. I. Efimov
BION
Author for correspondence.
Email: sefimov@bion-company.ru
Russian Federation, Kievskoe shosse 109 km, Obninsk, Kaluzhskaya obl., 249032
E. B. Pashkova
BION
Email: sefimov@bion-company.ru
Russian Federation, Kievskoe shosse 109 km, Obninsk, Kaluzhskaya obl., 249032
S. V. Stovbun
Semenov Institute of Chemical Physics
Email: sefimov@bion-company.ru
Russian Federation, ul. Kosygina 4, Moscow, 119991
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