Synthesis of New Purine Derivatives Containing α- and ω-Amino Acid Fragments

V. V. Musiyak; I. A. Nizova; T. V. Matveeva; G. L. Levit; V. P. Krasnov; V. N. Charushin

doi:10.1134/S1070428019060046

Synthesis of New Purine Derivatives Containing α- and ω-Amino Acid Fragments

Authors: Musiyak V.V.¹, Nizova I.A.¹, Matveeva T.V.¹, Levit G.L.¹, Krasnov V.P.¹, Charushin V.N.¹
Affiliations:
1. Postovskii Institute of Organic Synthesis, Ural Branch
Issue: Vol 55, No 6 (2019)
Pages: 762-770
Section: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/220711
DOI: https://doi.org/10.1134/S1070428019060046
ID: 220711

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Abstract

New conjugates of purine and 2-aminopurine with several α- and ω-amino acids have been synthesized following two approaches based on the condensation and nucleophilic substitution reactions. The enantiomeric purity of the isolated compounds has been confirmed by reversed-phase HPLC using a chiral stationary phase to demonstrate the absence of racemization during the synthesis. The conjugates are inactive against Mycobacterium tuberculosis H37Rv.