Synthesis of 1,3-Disubstituted Ureas Containing Cycloheptyl or Bicyclo[2.2.1]heptyl Fragments, as Soluble Epoxide Hydrolase Inhibitors

Abstract

To assess the effect of the lipophilicity of different parts of urea molecules on their activity as soluble epoxide hydrolase inhibitors, a series of 1,3-disubstituted ureas containing cycloheptane and bicyclo-[2.2.1]heptane fragments were prepared by the reaction of isocyanates with corresponding amines in 78–94% yields.