Отправить статью по E-mail Synthesis and Quantification of 2-(Diethylamino)-N-(2-methylphenyl)acetamide Nitrate
- Авторы: Chekryshkina L.A.1, Demin A.M.2, Tumashov A.A.2,3, Babikova E.A.4, Slepova N.V.1
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Учреждения:
- Perms State Pharmaceutical Academy, Ministry of Health of the Russian Federation
- Postovskii Institute of Organic Synthesis, Ural Branch
- Institute of Natural Sciences and Mathematics
- Pharmaceutical Branch
- Выпуск: Том 55, № 10 (2019)
- Страницы: 1532-1538
- Раздел: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/221265
- DOI: https://doi.org/10.1134/S1070428019100117
- ID: 221265
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Аннотация
A procedure for the synthesis of 2-(diethylamino)-N-(2-methylphenyl)acetamide nitrate (monomecaine) exhibiting a pronounced antiarrhythmic activity has been optimized. A procedure for its identification and quality control of the drug substance by HPLC has been developed, and the limit of detection of o-toluidine impurity therein has been estimated at 0.02%. Procedures for HLPC and extraction-titration quantification of monomekain in the drug substance have been proposed and validated. The obtained relative standard deviation (RSD) indicates good specificity, linearity, and precision of the developed procedures.
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Об авторах
L. Chekryshkina
Perms State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: demin@ios.uran.ru
Россия, Perm
A. Demin
Postovskii Institute of Organic Synthesis, Ural Branch
Автор, ответственный за переписку.
Email: demin@ios.uran.ru
Россия, Yekaterinburg
A. Tumashov
Postovskii Institute of Organic Synthesis, Ural Branch; Institute of Natural Sciences and Mathematics
Email: demin@ios.uran.ru
Россия, Yekaterinburg; Yekaterinburg
E. Babikova
Pharmaceutical Branch
Email: demin@ios.uran.ru
Россия, Yekaterinburg
N. Slepova
Perms State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: demin@ios.uran.ru
Россия, Perm
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