A One-Pot, Solvent-Free, and Catalyst-Free Synthesis of Substituted (E)-1-Phenyl-3-[2-(piperidin-1-yl)quinolin-3-yl]prop-2-en-1-ones Under Microwave Irradiation


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

A convenient one-pot, three-component, and solvent-free procedure for the preparation of substituted (E)-1-phenyl-3-[2-(piperidin-1-yl)quinolin-3-yl]prop-2-en-1-ones, which has made a significant improvement of previously reported methods, has been developed. The reaction of chloro aldehydes, ketones, and piperidine under microwave irradiation afforded the corresponding piperidine-substituted chalcone derivatives in high yields in shorter reaction times. All the synthesized compounds were characterized by IR and 1H and 13C NMR spectroscopy, and mass spectroscopy.

About the authors

V. K. Pujari

NewAge life Science Pvt Ltd, IDA Phase-II

Author for correspondence.
Email: pujarivijaykumar7@gmail.com
India, Mallapur, Hyderabad, Telangana

S. Vinnakota

Department of Chemistry

Email: pujarivijaykumar7@gmail.com
India, Donthanapally, Hyderabad, Telangana

R. K. Kakarla

Department of Chemistry

Email: pujarivijaykumar7@gmail.com
India, Medchal, Hyderabad, Telangana

S. Maroju

NewAge life Science Pvt Ltd, IDA Phase-II

Email: pujarivijaykumar7@gmail.com
India, Mallapur, Hyderabad, Telangana

A. Ganesh

Hypersynth Life Science, IDA Phase-II

Email: pujarivijaykumar7@gmail.com
India, Mallapur, Hyderabad, Telangana

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2019 Pleiades Publishing, Ltd.