Efficient Synthesis of 4-Phenyl-4 H -pyran Derivatives  via  a DIPEA-catalyzed One-Pot Three-Component Reaction

Jun Li; Jie Li; Shi-yu Hu; Ye Chen; Ju Liu

doi:10.1134/S107042801911023X

Efficient Synthesis of 4-Phenyl-4H-pyran Derivatives via a DIPEA-catalyzed One-Pot Three-Component Reaction

Authors: Li J.¹, Li J.¹, Hu S.¹, Chen Y.¹, Liu J.¹
Affiliations:
1. College of Pharmacy of Liaoning University, Key Laboratory of New Drug Research and Development of Liaoning Province
Issue: Vol 55, No 11 (2019)
Pages: 1791-1799
Section: Article
URL: https://journal-vniispk.ru/1070-4280/article/view/221425
DOI: https://doi.org/10.1134/S107042801911023X
ID: 221425

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Abstract

A novel one-pot approach has been developed for a high-yield synthesis of 4-phenyl-4H-pyran derivatives by the three-component condensation of dimethyl 3-oxopentanedioate or 3-oxo-3-arylpropanoic acid esters, aldehydes, with malononitrile in the presence of a DIPEA catalyst in ethanol at room temperature. The significant features of the present strategy include efficiency, high yield, inexpensive catalyst, mild reaction conditions, and simple purification procedure.