Efficient Synthesis of 4-Phenyl-4H-pyran Derivatives via a DIPEA-catalyzed One-Pot Three-Component Reaction


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Somente assinantes

Resumo

A novel one-pot approach has been developed for a high-yield synthesis of 4-phenyl-4H-pyran derivatives by the three-component condensation of dimethyl 3-oxopentanedioate or 3-oxo-3-arylpropanoic acid esters, aldehydes, with malononitrile in the presence of a DIPEA catalyst in ethanol at room temperature. The significant features of the present strategy include efficiency, high yield, inexpensive catalyst, mild reaction conditions, and simple purification procedure.

Sobre autores

Jun Li

College of Pharmacy of Liaoning University, Key Laboratory of New Drug Research and Development of Liaoning Province

Email: liuju1216@126.com
República Popular da China, 66 Chongshan Road, Huanggu District, Shenyang, 110036

Jie Li

College of Pharmacy of Liaoning University, Key Laboratory of New Drug Research and Development of Liaoning Province

Email: liuju1216@126.com
República Popular da China, 66 Chongshan Road, Huanggu District, Shenyang, 110036

Shi-yu Hu

College of Pharmacy of Liaoning University, Key Laboratory of New Drug Research and Development of Liaoning Province

Email: liuju1216@126.com
República Popular da China, 66 Chongshan Road, Huanggu District, Shenyang, 110036

Ye Chen

College of Pharmacy of Liaoning University, Key Laboratory of New Drug Research and Development of Liaoning Province

Autor responsável pela correspondência
Email: sy-chenye@163.com
República Popular da China, 66 Chongshan Road, Huanggu District, Shenyang, 110036

Ju Liu

College of Pharmacy of Liaoning University, Key Laboratory of New Drug Research and Development of Liaoning Province

Autor responsável pela correspondência
Email: liuju1216@126.com
República Popular da China, 66 Chongshan Road, Huanggu District, Shenyang, 110036

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Pleiades Publishing, Ltd., 2019