Synthesis of Benzo[h]quinazolines from Ethyl 1-Amino-3-cyclohexyl-3,4-dihydronaphthalene-2-carboxylate


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Abstract

The reaction of ethyl (2Z)-2-cyano-3-cyclohexylprop-2-enoate with benzylmagnesium chloride, followed by cyclization in the presence of sulfuric acid, provided an efficient method of synthesis of ethyl 1-amino-3-cyclohexyl-3,4-dihydronaphthalene-2-carboxylate which was converted to a number of new heterocyclic systems containing a benzo[h]quinazoline fragment.

About the authors

N. P. Grigoryan

Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry

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Email: nver-55@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014

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