Email this article Functionally Substituted Isothiazole- and Isoxazolecarboxamides
- Authors: Dikusar E.A.1, Petkevich S.K.1, Zhukovskaya N.A.1, Zvereva T.D.1, Kurman P.V.2
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Affiliations:
- Institute of Physical Organic Chemistry
- Institute of Bioorganic Chemistry
- Issue: Vol 55, No 4 (2019)
- Pages: 462-468
- Section: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/220249
- DOI: https://doi.org/10.1134/S1070428019040079
- ID: 220249
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Abstract
Convenient synthetic approaches to functionally substituted 5-phenyl-1,2-oxazole-3-carboxamides and 4,5-dichloro-1,2-thiazole-3-carboxamides were developed on the basis of reactions of the corresponding carboxylic acid chlorides with primary aromatic and aliphatic amines. Optimal ratios acid chloride—amine (or amine hydrochloride)–triethylamine were found so that the reaction did not involve active chlorine atom in position 5 of the isothiazole ring.
About the authors
E. A. Dikusar
Institute of Physical Organic Chemistry
Author for correspondence.
Email: dikusar@ifoch.bas-net.by
Belarus, Minsk
S. K. Petkevich
Institute of Physical Organic Chemistry
Email: dikusar@ifoch.bas-net.by
Belarus, Minsk
N. A. Zhukovskaya
Institute of Physical Organic Chemistry
Email: dikusar@ifoch.bas-net.by
Belarus, Minsk
T. D. Zvereva
Institute of Physical Organic Chemistry
Email: dikusar@ifoch.bas-net.by
Belarus, Minsk
P. V. Kurman
Institute of Bioorganic Chemistry
Email: dikusar@ifoch.bas-net.by
Belarus, Minsk
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