Synthesis of Tetrazoles Catalyzed by Novel Cobalt Magnetic Nanoparticles

Abstract

A novel magnetic Co nanoparticle catalyst was prepared by coating Fe₃0₄magnetic nanoparticles with tetraethyl orthosilicate functionalized with (3-chloropropyl)trimethoxysilane and 2-amino-5-mercapto-1,3,4-thiadiazole ligands followed by complexation with Co(OAc)₄. The catalyst was then characterized and applied for the synthesis of various tetrazoles by the reactions of amines with sodium azide and triethyl orthoformate in solvent-free conditions at 100°C.