New general synthesis of benzo[4,5]imidazo[1,2-a]pyrimidine and benzo[4,5]imidazo[2,1-b]quinazoline derivatives
- Авторлар: Harutyunyan A.A.1
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Мекемелер:
- Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
- Шығарылым: Том 52, № 7 (2016)
- Беттер: 1012-1017
- Бөлім: Article
- URL: https://journal-vniispk.ru/1070-4280/article/view/214703
- DOI: https://doi.org/10.1134/S1070428016070150
- ID: 214703
Дәйексөз келтіру
Аннотация
The reactions of benzene-1,2-diamine with 5-substituted 2-(alkylsulfanyl)-4-methylpyrimidin-6(1H)-ones and 2-(propylsulfanyl)- and 5-iodo-2-(propylsulfanyl)-3,4-dihydroquinazolines at 175–185°C under solvent-free conditions unexpectedly afforded benzo[4,5]imidazo[1,2-a]pyrimidine, benzo[4,5]imidazo[2,1-b]-quinazoline, and 2,2′-(benzene-1,2-diyldiimino)bis[pyrimidin-4(3H)-ones]. The described reaction is the first example of synthesis of these heterocyclic systems by fusion of benzimidazole to pyrimidine or quinazoline and is likely to follow ANRORC mechanism.
Авторлар туралы
A. Harutyunyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry
Хат алмасуға жауапты Автор.
Email: harutyunyan.arthur@yahoo.com
Армения, pr. Azatutyan 26, Yerevan, 0014
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